The roles of ATF3 in glucose homeostasis. A transgenic mouse model with liver dysfunction and defects in endocrine pancreas.

@article{AllenJennings2001TheRO,
  title={The roles of ATF3 in glucose homeostasis. A transgenic mouse model with liver dysfunction and defects in endocrine pancreas.},
  author={Amy E Allen-Jennings and Matthew G Hartman and Gary J. Kociba and Tsonwin Hai},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 31},
  pages={29507-14}
}
Activating transcription factor 3 (ATF3) is a member of the ATF/cAMP-response element-binding protein family of transcription factors. It is a transcriptional repressor, and the expression of its corresponding gene is induced by stress signals in a variety of tissues, including the liver. In this report, we demonstrate that ATF3 is induced in the pancreas by partial pancreatectomy, streptozotocin treatment, and ischemia coupled with reperfusion. Furthermore, ATF3 is induced in cultured islet… CONTINUE READING

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