The roles of ADP and TXA in botrocetin/VWF-induced aggregation of washed platelets.

@article{Liu2004TheRO,
  title={The roles of ADP and TXA in botrocetin/VWF-induced aggregation of washed platelets.},
  author={Jinglan Liu and Tamara I. Pestina and Michael C. Berndt and Shirley A. Steward and Carl Jackson and Theodore Kent Gartner},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2004},
  volume={2 12},
  pages={2213-22}
}
BACKGROUND Binding of von Willebrand factor (VWF) to the platelet membrane glycoprotein (GP) Ib-IX-V complex initiates a cascade of events leading to alphaIIbbeta3 activation and platelet aggregation. The roles of ADP and thromboxane A2 (TXA2) in agglutination-induced GPIbalpha-mediated platelet activation have not been fully described. METHODS Botrocetin and human VWF were used to stimulate washed mouse platelets. Platelets deficient in TXA2 receptors, Galphaq, or alphaIIbbeta3, and… CONTINUE READING

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