The roles of 5-HT1A and 5-HT2 receptors in the effects of 5-MeO-DMT on locomotor activity and prepulse inhibition in rats

  title={The roles of 5-HT1A and 5-HT2 receptors in the effects of 5-MeO-DMT on locomotor activity and prepulse inhibition in rats},
  author={K. Krebs-Thomson and E. M. Ruiz and V. Masten and Mah{\'a}lah R. Buell and M. Geyer},
  • K. Krebs-Thomson, E. M. Ruiz, +2 authors M. Geyer
  • Published 2006
  • Psychology, Medicine
  • Psychopharmacology
  • RationaleThe hallucinogen 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is structurally similar to other indoleamine hallucinogens such as LSD. The present study examined the effects of 5-MeO-DMT in rats using the Behavioral Pattern Monitor (BPM), which enables analyses of patterns of locomotor activity and exploration, and the prepulse inhibition of startle (PPI) paradigm.ObjectivesA series of interaction studies using the serotonin (5-HT)1A antagonist WAY-100635 (1.0 mg/kg), the 5-HT2A… CONTINUE READING
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