The role played by tumor necrosis factor during localized and systemic infection with Streptococcus pneumoniae.

@article{Kirby2005TheRP,
  title={The role played by tumor necrosis factor during localized and systemic infection with Streptococcus pneumoniae.},
  author={Alun C. Kirby and John Graham Raynes and Paul M. Kaye},
  journal={The Journal of infectious diseases},
  year={2005},
  volume={191 9},
  pages={1538-47}
}
Tumor necrosis factor (TNF) has been proposed as a major mediator of host resistance in murine models of Streptococcus pneumoniae infection; in humans, anti-TNF therapies have been implicated in increased susceptibility to pneumococcal infection. Here, we use nonlethal (serotype 6B) and lethal (serotype 3) S. pneumoniae, neutralizing monoclonal antibodies to TNF, and TNF gene-deficient mice to reexamine the role played by TNF in antistreptococcal responses. After nonlethal challenge, primary… CONTINUE READING
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