The role played by natural selection on Mendelian traits in humans.

Abstract

Detecting whether and how natural selection has targeted regions of the human genome represents a complementary strategy for identifying functionally important loci and variants involved in disease resistance and adaptation to the environment. In contrast with most complex diseases or traits, the genetic architecture of most Mendelian traits is relatively… (More)
DOI: 10.1111/j.1749-6632.2010.05856.x

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