The role of water in protein-DNA interactions.

  title={The role of water in protein-DNA interactions.},
  author={J W Schwabe},
  journal={Current opinion in structural biology},
  volume={7 1},
  • J W Schwabe
  • Published 1997 in Current opinion in structural biology
It is becoming well accepted that water plays an important role in both the specificity and affinity of protein-DNA interactions. Recently, a combination of structural, biochemical and thermodynamic techniques has particularly enhanced our understanding of the role of water in complexes between DNA and three different proteins: the trp repressor; the homeodomain; and the glucocorticoid receptor DNA-binding domain. 

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