The role of vitamin E (tocopherol) supplementation in the prevention of stroke. A meta-analysis of 13 randomised controlled trials.

@article{Bin2011TheRO,
  title={The role of vitamin E (tocopherol) supplementation in the prevention of stroke. A meta-analysis of 13 randomised controlled trials.},
  author={Q. Bin and Xueying Hu and Yun-fei Cao and F. Gao},
  journal={Thrombosis and haemostasis},
  year={2011},
  volume={105 4},
  pages={
          579-85
        }
}
It was the objective of this work to systematically evaluate the role of vitamin E supplementation in the prevention of stroke. Eligible studies were identified from Medline, Embase and Cochrane Library. The efficacy data is the relative risk (RR) for the events of stroke. Thirteen randomised controlled trials (RCTs), with 166,282 participants in total, were analysed. The pooled results showed no significant benefit in the vitamin E group with respect to stroke of any type (RR 1.01; 95… Expand
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In this meta-analysis, vitamin E increased the risk for haemorrhagic stroke by 22% and reduced the risk of ischaemic stroke by 10% and indiscriminate widespread use of vitamin E should be cautioned against. Expand
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Among the high-risk individuals that were studied, these antioxidant vitamins appeared to be safe, but, although this regimen increased blood vitamin concentrations substantially, it did not produce any significant reductions in the 5-year mortality from, or incidence of, any type of vascular disease, cancer, or other major outcome. Expand
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