The role of vitamin D in reducing cancer risk and progression

  title={The role of vitamin D in reducing cancer risk and progression},
  author={David Feldman and Aruna V. Krishnan and Srilatha Swami and Edward L. Giovannucci and Brian J Feldman},
  journal={Nature Reviews Cancer},
Vitamin D is not really a vitamin but the precursor to the potent steroid hormone calcitriol, which has widespread actions throughout the body. Calcitriol regulates numerous cellular pathways that could have a role in determining cancer risk and prognosis. Although epidemiological and early clinical trials are inconsistent, and randomized control trials in humans do not yet exist to conclusively support a beneficial role for vitamin D, accumulating results from preclinical and some clinical… 

The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention

It is indicated that vitamin D deficiency results in an increase in the risk of developing ovarian cancer and that vitamin supplements may potentially be an efficient way of preventing cancer.

The role of vitamin D in cancer prevention.

Vitamin D and Reduction of Breast Cancer Risk

  • J. LueK. Crew
  • Medicine, Biology
    Current Breast Cancer Reports
  • 2015
Despite some promising findings, further randomized controlled trials of vitamin D supplements are needed to determine the role ofitamin D in breast cancer prevention.

Vitamin D for Prevention and Treatment of Colorectal Cancer: What is the Evidence?

  • K. Ng
  • Medicine
    Current Colorectal Cancer Reports
  • 2014
There remains a great need to improve prognosis for patients with CRC, and investigating vitamin D as a potential therapy is an attractive option in regards to safety and cost, particularly in this era of expensive and often toxic anti-neoplastic agents.

Therapeutic effects of vitamin D and cancer: An overview

This review concentrates on different studies that have been conducted to characterize the outcome of vitamin D in reducing cancer incidence and its medication by cellular progression mechanism.

Role of Vitamin D in Breast Cancer Prevention and Therapy: Recent Findings

Accumulative findings support that vitamin D supplementation might reduce breast cancer risk, enhance effectiveness of chemotherapeutics and improve cancer survival.

Vitamin D and cancer; a contradictory problem

Both observational and experimental epidemiologic studies have reported that higher intakes of vitamin D are related to lower risk of cancer and enough intake could have a beneficial influence on some cancers.

Anticancer Effects of Vitamins

The relationship between vitamin D and cancer, as well as current clinical guidelines for the management of vitamin D deficiency, are reviewed.

Effect of Vitamin D3 Supplements on Development of Advanced Cancer

It is suggested that vitamin D3 may reduce the risk of developing advanced cancer among adults without a diagnosis of cancer at baseline; this protective effect is apparent for those who have normal but not elevated body mass index.



Vitamin D and colon cancer

  • C. DavisJ. Milner
  • Medicine, Biology
    Expert review of gastroenterology & hepatology
  • 2011
A wealth of scientific evidence supports a role for vitamin D in decreasing colorectal cancer incidence, and possibly mortality, and a critical evaluation of physiologically relevant biomarkers of vitamin D status is needed.

Current progress in using vitamin D and its analogs for cancer prevention and treatment

This review summarizes the preclinical and clinical studies of vitamin D and its analogs over the past decade, indicating the current problems of dose-limiting toxicity from hypercalcemia and large interpatient variability in pharmacokinetics.

Vitamin D: Considerations in the Continued Development as an Agent for Cancer Prevention and Therapy

Preclinical and epidemiologic data suggest that exposing cancer cells, as well as vascular endothelial cells derived from tumors, to high concentrations of active metabolites of vitamin D halts progression through cell cycle, induces apoptosis and will slow or stop the growth of tumors in vivo.

Vitamin D and cancer: a review of molecular mechanisms.

Although vitamin D-induced growth arrest and apoptosis of tumour cells or their non-neoplastic progenitors are plausible mechanisms, other chemoprotective mechanisms are also worthy of consideration and include enhancing DNA repair, antioxidant protection and immunomodulation.

Vitamin D signalling pathways in cancer: potential for anticancer therapeutics

The epidemiological, preclinical and clinical studies that support the development of 1α,25(OH)2D3 and vitamin D analogues as preventative and therapeutic anticancer agents are outlined.

The role of vitamin D in cancer prevention and treatment.

Vitamin D and prostate cancer.

  • S. BluttN. Weigel
  • Biology, Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1999
Funding is needed for further research into the mechanisms of vitamin D action in prostate and identification of suitable analogs for use in vivo, which may lead to its use in the treatment or prevention of prostate cancer.

Vitamin D analogs.

  • Glenville Jones
  • Biology, Medicine
    Endocrinology and metabolism clinics of North America
  • 2010

Vitamin D pathway gene variants and prostate cancer prognosis

Observational studies linking vitamin D deficiency with increased prostate cancer (PCa) mortality and the pleiotropic anticancer effects of vitamin D in malignant prostate cell lines have initiated