The role of virus-specific CD4+ T cells in the control of Epstein-Barr virus infection.

  title={The role of virus-specific CD4+ T cells in the control of Epstein-Barr virus infection.},
  author={Josef Mautner and Georg W. Bornkamm},
  journal={European journal of cell biology},
  volume={91 1},
Epstein-Barr virus (EBV) establishes lifelong persistent infections in humans and has been implicated in the pathogenesis of several human malignancies. Protective immunity against EBV is mediated by T cells, as indicated by an increased incidence of EBV-associated malignancies in immunocompromised patients, and by the successful treatment of EBV-associated post-transplant lymphoproliferative disease (PTLD) in transplant recipients by the infusion of polyclonal EBV-specific T cell lines. To… CONTINUE READING


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