The role of viral enhancer "core" motif-related sequences in regulating T cell receptor-gamma and -delta gene expression.

@article{Hsiang1993TheRO,
  title={The role of viral enhancer "core" motif-related sequences in regulating T cell receptor-gamma and -delta gene expression.},
  author={Yanyu Hsiang and Donald S. Spencer and Siying Wang and Nancy A Speck and David H Raulet},
  journal={Journal of immunology},
  year={1993},
  volume={150 9},
  pages={
          3905-16
        }
}
T cells express clonally distributed alpha beta or gamma delta Ag receptor heterodimers. Transcriptional enhancers for the genes of all four subunits are active in both gamma delta and alpha beta T cells, but are less active or inactive in other cells. Conserved sequence motifs are present in all four enhancers, suggesting that common transcription factors regulate TCR gene expression. One of these motifs in the gamma 3 site of the TCR-gamma enhancer is similar to motifs found in several other… CONTINUE READING

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