The role of vesicular transport in ABCA1-dependent lipid efflux and its connection with NPC pathways

@article{Boadu2005TheRO,
  title={The role of vesicular transport in ABCA1-dependent lipid efflux and its connection with NPC pathways},
  author={Emmanuel Boadu and Gordon A. Francis},
  journal={Journal of Molecular Medicine},
  year={2005},
  volume={84},
  pages={266-275}
}
The membrane transporter ATP-binding cassette transporter A1 (ABCA1) has been shown to be the rate-limiting step in the initial formation of plasma high-density lipoprotein (HDL) particles. The mechanisms of action of ABCA1, including its role in the vesicular transport of lipids to the cell surface for the lipidation of HDL apolipoproteins, are not fully understood. Niemann–Pick type C (NPC) disease is most often caused by mutations in the NPC1 gene, whose protein product is believed to… CONTINUE READING