The role of vascular growth factors in hyperoxia-induced injury to the developing lung.

@article{DAngio2002TheRO,
  title={The role of vascular growth factors in hyperoxia-induced injury to the developing lung.},
  author={Carl T. D'Angio and William M. Maniscalco},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2002},
  volume={7},
  pages={d1609-23}
}
Normal pulmonary vascular development is the result of a complex interplay of growth factors, including vascular endothelial growth factor (VEGF) and the angiopoietins. Injury to the developing lung, whether due to hyperoxia or mechanical ventilation, results in disordered vascular development, ranging from an apparent arrest of microvascular development in milder injury to extensive microvascular derangement in more severe injury. Alterations in vascular growth factors may participate in these… CONTINUE READING