The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors.

@article{Jain2009TheRO,
  title={The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors.},
  author={Lokesh Jain and Craig A. Vargo and Romano Danesi and Tristan Sissung and Douglas K. Price and David J Venzon and J{\"u}rgen Venitz and William D. Figg},
  journal={Molecular cancer therapeutics},
  year={2009},
  volume={8 9},
  pages={2496-508}
}
Angiogenesis is crucial for development and metastasis of tumors, and vascular endothelial growth factor (VEGF) is a key mediator of this process. The importance of VEGF in tumorigenesis and tumor progression makes it an attractive target for the development of anticancer therapies. Inhibition of angiogenesis has shown promising clinical efficacy; however, not all patients treated with antiangiogenic agents derive benefit from them. Some patients are predisposed to refractory disease, whereas… CONTINUE READING