The role of uptake2 in the extraneuronal metabolism of catecholamines in the isolated rat heart.

@article{Lightman1969TheRO,
  title={The role of uptake2 in the extraneuronal metabolism of catecholamines in the isolated rat heart.},
  author={Stafford L. Lightman and Leslie Lars Iversen},
  journal={British journal of pharmacology},
  year={1969},
  volume={37 3},
  pages={638-49}
}
1. (+/-)-(3)H-NA and labelled metabolites of NA were estimated in rat hearts after perfusion with various concentrations of NA in the range 0.01-50.0 mug/ml. Labelled metabolites of NA accounted for only a small proportion of the total uptake of radioactivity at low perfusion concentrations, but accounted for 50% of the total uptake at 1 mug NA/ml., thereafter declining to progressively smaller proportions at higher perfusion concentrations.2. If the formation of labelled metabolites of (3)H-NA… CONTINUE READING

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