The role of uncoupling proteins in pathophysiological states.

  title={The role of uncoupling proteins in pathophysiological states.},
  author={Josep Maria Argil{\'e}s and S{\'i}lvia Busquets and Francisco Javier L{\'o}pez-Soriano},
  journal={Biochemical and biophysical research communications},
  volume={293 4},
Until very recently, the uncoupling protein-1 (UCP1), present only in brown adipose tissue (BAT), was considered to be the only mitochondrial carrier protein that stimulated heat production by dissipating the proton gradient generated during respiration across the inner mitochondrial membrane and therefore uncoupling respiration from ATP synthesis. Recently, new uncoupling proteins, UCP2, UCP3, and UCP4, and brain mitochondrial carrier protein-1 (BMCP-1) have been described in mammalian tissues… CONTINUE READING


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