The role of tyrosine-158 in O6-alkylguanine-DNA alkyltransferase activity.

@article{Edara1995TheRO,
  title={The role of tyrosine-158 in O6-alkylguanine-DNA alkyltransferase activity.},
  author={Suvarchala Edara and Karma Goodtzova and Anthony E. Pegg},
  journal={Carcinogenesis},
  year={1995},
  volume={16 7},
  pages={
          1637-42
        }
}
The tyrosine residue present at position 158 in the human O6-alkylguanine-DNA alkyltransferase is one of 22 amino acid residues that are conserved in all known alkyltransferase protein sequences. The importance of this amino acid in the reactions brought about by the alkyltransferase was studied by changing this residue to alanine or to phenylalanine. The control and mutant alkyltransferase proteins were expressed in an Escherichia coli strain lacking alkyltransferase activity and the proteins… CONTINUE READING

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