The role of tyrosine-114 in the enzymatic activity of the Shiga-like toxin I A-chain

@article{Deresiewicz1993TheRO,
  title={The role of tyrosine-114 in the enzymatic activity of the Shiga-like toxin I A-chain},
  author={Robert L. Deresiewicz and Paula R. Austin and Carolyn J. Hovde},
  journal={Molecular and General Genetics MGG},
  year={1993},
  volume={241},
  pages={467-473}
}
Shiga-like toxin I (SLT-I), the potent cytotoxin produced by certain pathogenic strains of Escherichia coli, is a member of a burgeoning family of ribosome-inactivating proteins (RIPS), which share common structural and mechanistic features. The prototype of the group is the plant toxin ricin. Recently we proposed a structural model for the Slt-IA active… CONTINUE READING