The role of tumour necrosis factor (TNF-alpha) in experimental autoimmune uveoretinitis (EAU).

@article{Dick2004TheRO,
  title={The role of tumour necrosis factor (TNF-alpha) in experimental autoimmune uveoretinitis (EAU).},
  author={Andrew D Dick and John V. Forrester and Janet Liversidge and Andrew P Cope},
  journal={Progress in retinal and eye research},
  year={2004},
  volume={23 6},
  pages={617-37}
}
The pleiotropic cytokine tumour necrosis factor-alpha (TNF-alpha) is released from cells that include macrophages and T-cells during inflammatory responses, orchestrating the initiation of further leucocytic infiltration via adhesion molecule upregulation, dendritic cell maturation and survival, macrophage activation and driving Th1 T-cells responses within tissues. Exposure to TNF also plays a role in maintaining tissue homeostasis, particularly relating to resident cell responses of both… CONTINUE READING

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