The role of tumour-derived iNOS in tumour progression and angiogenesis

@inproceedings{Kostourou2011TheRO,
  title={The role of tumour-derived iNOS in tumour progression and angiogenesis},
  author={Vassiliki Kostourou and Judith E. Cartwright and Alan P. Johnstone and Jessica Kr Boult and Elizabeth R Cullis and GStJ Whitley and Simon P Robinson},
  booktitle={British Journal of Cancer},
  year={2011}
}
Background:Progressive tumour growth is dependent on the development of a functional tumour vasculature and highly regulated by growth factors and cytokines. Nitric oxide (NO) is a free radical, produced both by tumour and host cells, and functions as a signalling molecule downstream of several angiogenic factors. Both pro- and antitumourigenic properties have been attributed to NO.Methods:The expression of the inducible isoform of NO synthase (iNOS) was knocked down in the C6 glioma cell line… CONTINUE READING

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