The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies

  title={The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies},
  author={L. Bingle and N. Brown and C. Lewis},
  journal={The Journal of Pathology},
  • L. Bingle, N. Brown, C. Lewis
  • Published 2002
  • Biology, Medicine
  • The Journal of Pathology
  • The role of macrophages in tumour growth and development is complex and multifaceted. Whilst there is limited evidence that tumour‐associated macrophages (TAMs) can be directly tumouricidal and stimulate the anti‐tumour activity of T cells, there is now contrasting evidence that tumour cells are able to block or evade the activity of TAMs at the tumour site. In some cases, tumour‐derived molecules even redirect TAM activities to promote tumour survival and growth. Indeed, evidence has emerged… CONTINUE READING
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