The role of tumor-associated macrophages in tumor vascularization

@article{Guo2013TheRO,
  title={The role of tumor-associated macrophages in tumor vascularization},
  author={Chunqing Guo and Annicole Buranych and Devanand Sarkar and Paul B Fisher and Xiang-Yang Wang},
  journal={Vascular Cell},
  year={2013},
  volume={5},
  pages={20 - 20}
}
Tumor vascularization is a highly complex process that involves the interaction between tumors and their surrounding stroma, as well as many distinct angiogenesis-regulating factors. Tumor associated macrophages (TAMs) represent one of the most abundant cell components in the tumor environment and key contributors to cancer-related inflammation. A large body of evidence supports the notion that TAMs play a critical role in promoting the formation of an abnormal tumor vascular network and… 
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Information about the role of TAMs on modulating angiogenesis in the inflammatory micro-environment of solid tumors is summarized and the potential targets for future therapeutic approaches are discussed.
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Depletion of TAM or their “re-education” as antitumor effectors is under clinical investigation and hopefully will contribute to the efficacy of conventional anti-cancer treatments.
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Versican and TAMs are suggested as attractive targets for breast cancer therapy due to their links to a pro-inflammatory and pro-angiogenic state in the primary tumor.
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