The role of tryptophan residues in the function and stability of the mechanosensitive channel MscS from Escherichia coli.

Abstract

Tryptophan (Trp) residues play important roles in many proteins. In particular they are enriched in protein surfaces involved in protein docking and are often found in membrane proteins close to the lipid head groups. However, they are usually absent from the membrane domains of mechanosensitive channels. Three Trp residues occur naturally in the… (More)

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