The role of transthyretin in the transport of thyroid hormone to cerebrospinal fluid and brain.

@article{Chanoine1992TheRO,
  title={The role of transthyretin in the transport of thyroid hormone to cerebrospinal fluid and brain.},
  author={J P Chanoine and Lewis E. Braverman},
  journal={Acta medica Austriaca},
  year={1992},
  volume={19 Suppl 1},
  pages={25-8}
}
Cerebrospinal fluid (CSF) transthyretin (TTR), the main CSF thyroxine (T4) carrier protein in the rat and the human is synthesized in the choroid plexus (CP). After injection of 125I-T4 in the rat, radioactive T4 accumulates first in the CP, then in the CSF and later in the brain. We have shown that competitive inhibition of T4-TTR binding sites in the CP and CSF by a flavonoid results in a decrease in the radioactivity present in the brain after i.v. injection of 125I-T4, suggesting that T4… CONTINUE READING

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