The role of transmembrane channel–like proteins in the operation of hair cell mechanotransducer channels

@inproceedings{Kim2013TheRO,
  title={The role of transmembrane channel–like proteins in the operation of hair cell mechanotransducer channels},
  author={Kyunghee X. Kim and Maryline Beurg and Carole M. Hackney and David N Furness and Shanthini Mahendrasingam and Robert Fettiplace},
  booktitle={The Journal of general physiology},
  year={2013}
}
Sound stimuli elicit movement of the stereocilia that make up the hair bundle of cochlear hair cells, putting tension on the tip links connecting the stereocilia and thereby opening mechanotransducer (MT) channels. Tmc1 and Tmc2, two members of the transmembrane channel-like family, are necessary for mechanotransduction. To assess their precise role, we recorded MT currents elicited by hair bundle deflections in mice with null mutations of Tmc1, Tmc2, or both. During the first postnatal week… CONTINUE READING
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