The role of transient receptor potential vanilloid-1 on neural responses to acids by the chorda tympani, glossopharyngeal and superior laryngeal nerves in mice

@article{Arai2010TheRO,
  title={The role of transient receptor potential vanilloid-1 on neural responses to acids by the chorda tympani, glossopharyngeal and superior laryngeal nerves in mice},
  author={Tomoko Arai and Tadahiro Ohkuri and Keiko Yasumatsu and Toyoaki Kaga and Yuzo Ninomiya},
  journal={Neuroscience},
  year={2010},
  volume={165},
  pages={1476-1489}
}
The transient receptor potential vanilloid-1 (TRPV1) receptor acts as a polymodal nociceptor activated by capsaicin, heat, and acid. TRPV1, which is expressed in sensory neurons innervating the oral cavity, is associated with an oral burning sensation in response to spicy food containing capsaicin. However, little is known about the involvement of TRPV1 in responses to acid stimuli in either the gustatory system or the general somatosensory innervation of the oropharynx. To test this… Expand
A TRPA1-dependent mechanism for the pungent sensation of weak acids
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It is concluded that TRPA1 is a general sensor for weak acids that produce intracellular acidification and suggest that it functions within the pain pathway to mediate sensitivity to cellular acidosis. Expand
Genetic Deletion of TrpV1 and TrpA1 Does not Alter Avoidance of or Patterns of Brainstem Activation to Citric Acid in Mice.
TLDR
Examination of avoidance responses in wildtype and TrpA1/V1 double KO mice and induction of c-Fos in the nTS and dorsomedial spinal trigeminal nucleus was similar, suggestingNon-TrpV1 and non-TrPA1 receptors underlie the residual responses to acids in mice lacking taste function. Expand
Genetic Deletion of TrpV1 and TrpA1 Does not Alter Avoidance of or Patterns of Brainstem Activation to Citric Acid in Mice
TLDR
Examination of avoidance responses in wildtype and TrpA1/V1 double KO mice and induction of c-Fos in the nTS and dorsomedial spinal trigeminal nucleus was similar, suggestingNon-TrpV1 and non-TrPA1 receptors underlie the residual responses to acids in mice lacking taste function. Expand
Contribution of the TRPV1 channel to salt taste quality in mice as assessed by conditioned taste aversion generalization and chorda tympani nerve responses.
TLDR
TRPV1 did not appear to contribute to sodium salt perception based on gustatory signals, at least in the CT, but may have contributed to the oral somatosensory features of sodium. Expand
Dissecting the role of TRPV1 in detecting multiple trigeminal irritants in three behavioral assays for sensory irritation
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TRPV1 knockouts showed deficiencies in the detection of benzaldehyde, cyclohexanone and eugenol in at least one assay, but cyclo hexanone was the only substance tested that appears to act solely through TRPV 1. Expand
Residual chemoresponsiveness to acids in the superior laryngeal nerve in "taste-blind" (P2X2/P2X3 double-KO) mice.
TLDR
Results are consistent with the hypothesis that the residual avoidance of acidic solutions by P2X-dblKO mice may be attributable to the direct chemosensitivity of nerve fibers innervating the laryngeal epithelium and not to taste. Expand
TRPs in taste and chemesthesis.
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  • Chemistry, Medicine
  • Handbook of experimental pharmacology
  • 2014
TRP channels are expressed in taste buds, nerve fibers, and keratinocytes in the oronasal cavity. These channels play integral roles in transducing chemical stimuli, giving rise to sensations ofExpand
Modulation of central gustatory coding by temperature.
TLDR
Electrophysiologically recorded orosensory responses from 39 taste-sensitive neurons in the nucleus tractus solitarii of anesthetized mice during oral delivery of tastants adjusted to innocuous cool, room, and warm oral temperatures, showing temperature is a parameter of gustatory processing, like taste quality and concentration, in medullary circuits for taste. Expand
Physiological and Behavioral Responses to Optogenetic Stimulation of PKD2L1+ Type III Taste Cells
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The results suggest that the responses of NST cells to cation salt ions are regulated differentially. Expand
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