The role of transforming growth factor-α on mucin overproduction in eosinophilic chronic rhinosinusitis.

@article{Ishinaga2011TheRO,
  title={The role of transforming growth factor-α on mucin overproduction in eosinophilic chronic rhinosinusitis.},
  author={Hajime Ishinaga and Said Ahmad Shah and Hiroshi Sakaida and Kazuhiko Takeuchi},
  journal={Pharmacology},
  year={2011},
  volume={88 5-6},
  pages={302-8}
}
OBJECTIVES Eosinophilic chronic rhinosinusitis (ECRS) is considered a refractory and intractable disease with thick mucus production, long-term nasal congestion, loss of sense of smell and intermittent acute exacerbations secondary to bacterial infections. In this study, we investigated which growth factor is deeply involved in the mucin overproduction in ECRS. METHOD We employed fluorescence immunohistochemical analysis to evaluate whether or not TGF-α expression was upregulated in the nasal… CONTINUE READING