The role of transferrin-receptor variation in the host range of Trypanosoma brucei

@article{Bitter1998TheRO,
  title={The role of transferrin-receptor variation in the host range of Trypanosoma brucei},
  author={Wilbert Bitter and Herlinde Gerrits and R. N. Kieft and Piet Borst},
  journal={Nature},
  year={1998},
  volume={391},
  pages={499-502}
}
Trypanosoma brucei1 is a unicellular parasite transmitted between African mammals by tsetse flies. T. brucei multiplies freely in the bloodstream of many different mammals, and survives by antigenic variation of the main component of its surface coat, variant surface glycoprotein (VSG)2,3. Trypanosomes take up transferrin through a heterodimeric transferrin receptor4,5,6,7,8,9, the genes for which are expressed in telomeric expression sites along with the VSG gene. There are up to 20 of these… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 63 CITATIONS, ESTIMATED 62% COVERAGE

Genetic Variability of ESAG 6 / 7 Gene Isolat Trypanosoma evansi

DH Sawitri, Wardhana
  • 2018
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1999
2018

CITATION STATISTICS

  • 9 Highly Influenced Citations