The role of transcriptional coactivator TRAP220 in myelomonocytic differentiation.

  title={The role of transcriptional coactivator TRAP220 in myelomonocytic differentiation.},
  author={Norinaga Urahama and Mitsuhiro Ito and Akiko Sada and Kimikazu Yakushijin and Katsuya Yamamoto and Atsuo Okamura and Kentaro Minagawa and Akio Hato and Kazuo Chihara and Robert G Roeder and Toshimitsu Matsui},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  volume={10 12},
The TRAP220 subunit of the thyroid hormone receptor-associated polypeptide transcription coactivator complex (TRAP/Mediator complex), mammalian counterpart of the yeast Mediator complex, is proposed to act on a variety of major and specific biological events through physical interactions with nuclear receptors. The vitamin D receptor (VDR) and retinoic acid receptor (RAR), coupled with retinoid X receptor (RXR), are nuclear receptors which have important roles for monopoiesis and granulopoiesis… CONTINUE READING


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