The role of toll-like receptor 4 in airway inflammation induced by diesel exhaust particles

@article{Inoue2005TheRO,
  title={The role of toll-like receptor 4 in airway inflammation induced by diesel exhaust particles},
  author={Ken-ichiro Inoue and Hirohisa Takano and Rie Yanagisawa and Seishiro Hirano and Takamichi Ichinose and Akinori Shimada and Toshikazu Yoshikawa},
  journal={Archives of Toxicology},
  year={2005},
  volume={80},
  pages={275-279}
}
Although several studies have demonstrated that airway exposure to diesel exhaust particles (DEP) induces lung inflammation, the signaling pathways involved in the pathogenesis remain unclear. Toll-like receptors (TLRs) are generally accepted to be pathogen recognition receptors in mammalians. In the present study, we investigated the role of TLR-4 in DEP-induced lung inflammation and cytokine expression in the lung in TLR-4 point mutant (C3H/HeJ) mice and corresponding control (C3H/HeN) mice… CONTINUE READING