The role of titration schedule of topiramate for the development of depression in patients with epilepsy.

@article{Mula2009TheRO,
  title={The role of titration schedule of topiramate for the development of depression in patients with epilepsy.},
  author={Marco Mula and Dale C Hesdorffer and Michael Robert Trimble and Josemir W. Sander},
  journal={Epilepsia},
  year={2009},
  volume={50 5},
  pages={1072-6}
}
PURPOSE To determine whether a fast titration schedule of topiramate (TPM) has different effects on the occurrence of depression, in relation to other risk factors for TPM-induced depression, including history of depression (HxDEP), febrile seizures (FS), and hippocampal sclerosis (HS). METHODS Using data from a large case registry of patients prescribed TPM, two models were constructed: Model 1 examined the independent effect of rapid TPM titration after separate adjustment for FS, HxDEP… CONTINUE READING