The role of thromboxane in primate endotoxin shock.

  title={The role of thromboxane in primate endotoxin shock.},
  author={Larry Casey and J. Raymond Fletcher and M I Zmudka and Peter W. Ramwell},
  journal={The Journal of surgical research},
  volume={39 2},
UNLABELLED Previous studies have suggested an important role of thromboxane (Tx) in the pathogenesis of endotoxin shock in the rat. The present study evaluated the role of thromboxane in an LD70 primate model of endotoxin shock by administering 6 mg/kg of endotoxin to three groups of animals that were pretreated with either saline (5 ml), OKY 1581 (2 mg/kg, 10 min prior), or imidazole (25 mg/kg/hr starting 30 min prior), groups I, II, and III, respectively. There were significant differences… CONTINUE READING