The role of thrombospondin-1 in tumor progression and angiogenesis.

  title={The role of thrombospondin-1 in tumor progression and angiogenesis.},
  author={George P. Tuszynski and Roberto Francesco Nicosia},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={18 1},
Thrombospondin (TSP-1) is a large glycoprotein secreted by platelets and synthesized by many cell types, including endothelial and tumor cells. Although controversy exists about the biological function of TSP-1, the following observations suggest that TSP-1 may potentiate tumor progression. (1) Tumor metastases in mice are promoted by TSP-1 and inhibited by anti-TSP-1 antibodies. (2) TSP-1 promotes tumor cell adhesion, migration and invasion. (3) TSP-1 promotes angiogenesis in the rat aorta… CONTINUE READING