The role of third-generation beta-blocking agents in chronic heart failure.

@article{Bristow1998TheRO,
  title={The role of third-generation beta-blocking agents in chronic heart failure.},
  author={Michael R. Bristow and Robert L Roden and Brian D. Lowes and Edward M. Gilbert and Eric J. Eichhorn},
  journal={Clinical cardiology},
  year={1998},
  volume={21 12 Suppl 1},
  pages={I3-13}
}
Third-generation beta-blocking agents developed for the hypertension market are proving useful in the treatment of chronic heart failure (HF). These compounds share the ancillary property of vasodilation, which improves acute tolerability by unloading the failing left ventricle at a time when beta-adrenergic withdrawal produces myocardial depression. In the case of carvedilol and bucindolol, this allows for the administration of nonselective beta blockade. Because of blockade of both beta 1 and… CONTINUE READING
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