The role of thioredoxin reductase activity in selenium-induced cytotoxicity.

  title={The role of thioredoxin reductase activity in selenium-induced cytotoxicity.},
  author={Zbigniew Madeja and Jolanta Sroka and Christina Nystr{\"o}m and Linda Bj{\"o}rkhem-Bergman and Tomas Nordman and Anastasios E. Damdimopoulos and Ivan Nalvarte and Lennart C. Eriksson and Giannis Spyrou and Jerker M Olsson and Mikael Bj{\"o}rnstedt},
  journal={Biochemical pharmacology},
  volume={69 12},
The selenoprotein thioredoxin reductase is a key enzyme in selenium metabolism, reducing selenium compounds and thereby providing selenide to synthesis of all selenoproteins. We evaluated the importance of active TrxR1 in selenium-induced cytotoxicity using transfected TrxR1 over-expressing stable Human Embryo Kidney (HEK-293) cells and modulation of activity by pretreatment with low concentration of selenite. Treatment with sodium selenite induced cytotoxity in a dose-dependent manner in both… CONTINUE READING
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