The role of the yeast ATP-binding cassette Ycf1p in glutathione and cadmium ion homeostasis during respiratory metabolism.

@article{MielniczkiPereira2008TheRO,
  title={The role of the yeast ATP-binding cassette Ycf1p in glutathione and cadmium ion homeostasis during respiratory metabolism.},
  author={Albanin Aparecida Mielniczki-Pereira and Ana Zilles Schuch and Diego Bonatto and C{\'a}tia Ferreira Cavalcante and Delmo Santiago Vaitsman and Cristiano Jorge Riger and Elis Cristina Ara{\'u}jo Eleuth{\'e}rio and Jo{\~a}o Antonio P{\^e}gas Henriques},
  journal={Toxicology letters},
  year={2008},
  volume={180 1},
  pages={21-7}
}
Cadmium (Cd2+) is a toxic environmental contaminant for biological systems, which can form complexes with reduced glutathione (GSH), and thus alter the intracellular redox state. In Saccharomyces (S.) cerevisiae, bis(glutathionato)cadmium (Cd-[GS]2) complexes can be removed from the cytosol and transported into the vacuole by a glutathione-conjugated pump, Ycf1p. In this study, we investigated the role of Ycf1p in Cd2+ detoxification during respiratory metabolism of S. cerevisiae, and the… CONTINUE READING

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