The role of the ventromedial nucleus of the hypothalamus in epileptogenesis

@article{Ferland1998TheRO,
  title={The role of the ventromedial nucleus of the hypothalamus in epileptogenesis},
  author={Russell J. Ferland and Craig D. Applegate},
  journal={NeuroReport},
  year={1998},
  volume={9},
  pages={3623–3629}
}
FLUROTHYL kindling initiates a time-dependent process that results in a facilitated propagation from the fore-brain to the brainstem seizure system and in an increase in the complexity of behavioral seizure expression. We investigated the involvement of the ventromedial nucleus of the hypothalamus (VMH) in mediating this facilitated propagation between these seizure systems. Bilateral ibotenic acid lesions of the VMH, but not the dorsomedial nucleus of the hypothalamus (DMH), resulted in a… 
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The Repeated Flurothyl Seizure Model in Mice.
TLDR
The repeated flurothyl seizure model of epileptogenesis, as described here, may aid in providing insight into these important epilepsy issues in addition to understanding how spontaneous seizures develop.
Persistent regional increases in brain-derived neurotrophic factor in the flurothyl model of epileptogenesis are dependent upon the kindling status of the animal
The Effects of Brain-Irradiation-Induced Decreases in Hippocampal Mitotic Activity on Flurothyl-Induced Epileptogenesis in Adult C57BL/6J Mice
TLDR
Results suggest that seizure-induced increases in mitotic activity in the hippocampal dentate gyrus are not directly related to the processes that underlie the shift in behavioral seizure phenotype or in either the induction or the maintenance of lowered seizure threshold that is observed in this flurothyl model of epileptogenesis.
Comparative fos immunoreactivity in the brain after forebrain, brainstem, or combined seizures induced by electroshock, pentylenetetrazol, focally induced and audiogenic seizures in rats
Increased mitotic activity in the dentate gyrus of the hippocampus of adult C57BL/6J mice exposed to the flurothyl kindling model of epileptogenesis
Dissociation of spontaneous seizures and brainstem seizure thresholds in mice exposed to eight flurothyl‐induced generalized seizures
TLDR
Mice develop a complex seizure semiology originating in the forebrain and propagating into the brainstem seizure network (a forebrain→brainstem seizure) in contrast to seizure‐sensitive DBA/2J mice, which do not experience a change in seizure phenotype following a 28‐day incubation period and subsequent flurothyl rechallenge.
Parsing the Network Mechanisms of Electroconvulsive Therapy
Spatiotemporal differences in the c-fos pathway between C57BL/6J and DBA/2J mice following flurothyl-induced seizures: A dissociation of hippocampal Fos from seizure activity
Behavioral and metabolic features of repetitive seizures in immature and mature rats
Dissociation of seizure traits in inbred strains of mice using the flurothyl kindling model of epileptogenesis
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References

SHOWING 1-10 OF 16 REFERENCES
THE ROLE OF THE PIRIFORM CORTEX IN KINDLING
A Role for the Bilateral Involvement of Perirhinal Cortex in Generalized Kindled Seizure Expression
TLDR
A role for the bilateral involvement of the PRh in generalized clonic seizure expression whether evoked from the naive or kindled state is indicated and results indicate that bilateral behaviors require the bilateral involved of the structures necessary for the expression of these behaviors.
Pyriform cortex involvement in kindling
Kindling in the perirhinal cortex
Partial kindling of the ventral hippocampus: Identification of changes in limbic physiology which accompany changes in feline aggression and defense
  • R. Adamec
  • Biology, Psychology
    Physiology & Behavior
  • 1991
Decreased brainstem seizure thresholds and facilitated seizure propagation in mice exposed to repeated flurothyl-induced generalized forebrain seizures
The efferent connections of the ventromedial nucleus of the hypothalamus of the rat ,
TLDR
The efferent connections of the ventromedial nucleus of the hypothalamus (VMH) of the rat have been examined using the autoradiographic method to identify labeled axons which follow a ventral amygdalopetal route from the lateral hypothalamic area and ventral supraoptic commissure.
Regional analysis of the spatial patterns of Fos induction in brain following flurothyl kindling
Neuronal processes that underlie expression of kindled epileptiform events in the piriform cortex in vivo
  • L. Haberly, T. Sutula
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1992
TLDR
An important finding was that the EPSP generated by this associational pathway was completely blocked in cell bodies of pyramidal cells in piriform cortex by the IPSP during most events, suggesting this IPSP may play a critical role in limiting seizure activity by preventing reverberating positive feedback in thePyramidal cell population.
The role of the pyriform cortex in the generation of interictal spikes in the kindled preparation
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