The role of the ventromedial nucleus of the hypothalamus in epileptogenesis

@article{Ferland1998TheRO,
  title={The role of the ventromedial nucleus of the hypothalamus in epileptogenesis},
  author={Russell J. Ferland and Craig D. Applegate},
  journal={NeuroReport},
  year={1998},
  volume={9},
  pages={3623–3629}
}
FLUROTHYL kindling initiates a time-dependent process that results in a facilitated propagation from the fore-brain to the brainstem seizure system and in an increase in the complexity of behavioral seizure expression. We investigated the involvement of the ventromedial nucleus of the hypothalamus (VMH) in mediating this facilitated propagation between these seizure systems. Bilateral ibotenic acid lesions of the VMH, but not the dorsomedial nucleus of the hypothalamus (DMH), resulted in a… 
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The repeated flurothyl seizure model of epileptogenesis, as described here, may aid in providing insight into these important epilepsy issues in addition to understanding how spontaneous seizures develop.
The Effects of Brain-Irradiation-Induced Decreases in Hippocampal Mitotic Activity on Flurothyl-Induced Epileptogenesis in Adult C57BL/6J Mice
TLDR
Results suggest that seizure-induced increases in mitotic activity in the hippocampal dentate gyrus are not directly related to the processes that underlie the shift in behavioral seizure phenotype or in either the induction or the maintenance of lowered seizure threshold that is observed in this flurothyl model of epileptogenesis.
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TLDR
Mice develop a complex seizure semiology originating in the forebrain and propagating into the brainstem seizure network (a forebrain→brainstem seizure) in contrast to seizure‐sensitive DBA/2J mice, which do not experience a change in seizure phenotype following a 28‐day incubation period and subsequent flurothyl rechallenge.
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References

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TLDR
A role for the bilateral involvement of the PRh in generalized clonic seizure expression whether evoked from the naive or kindled state is indicated and results indicate that bilateral behaviors require the bilateral involved of the structures necessary for the expression of these behaviors.
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Kindling in the perirhinal cortex
The efferent connections of the ventromedial nucleus of the hypothalamus of the rat ,
TLDR
The efferent connections of the ventromedial nucleus of the hypothalamus (VMH) of the rat have been examined using the autoradiographic method to identify labeled axons which follow a ventral amygdalopetal route from the lateral hypothalamic area and ventral supraoptic commissure.
Neuronal processes that underlie expression of kindled epileptiform events in the piriform cortex in vivo
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  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
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TLDR
An important finding was that the EPSP generated by this associational pathway was completely blocked in cell bodies of pyramidal cells in piriform cortex by the IPSP during most events, suggesting this IPSP may play a critical role in limiting seizure activity by preventing reverberating positive feedback in thePyramidal cell population.
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