The role of the vagus nerve in fibromyalgia syndrome

  title={The role of the vagus nerve in fibromyalgia syndrome},
  author={Daniel Fernandes Martins and Fr{\'e}d{\'e}ric J. F. Viseux and Daiana C Salm and Anny Caroline Avelino Ribeiro and Helen Kassiana Lopes da Silva and Lynsey A. Seim and Edsel B. Bittencourt and Gianluca Bianco and Ari Ojeda Ocampo Mor{\'e} and William R. Reed and Leidiane Mazzardo-Martins},
  journal={Neuroscience \& Biobehavioral Reviews},
Can Hormonal Contraceptive Therapy be a useful treatment in Fibromyalgia? A Case Report
  • A. Musto, M. Camici
  • Medicine, Psychology
    Archives of Clinical and Medical Case Reports
  • 2022
A case of a young adult female affected by deep endometriosis, who developed FM symptoms soon after the interruption of the continuous contraceptive treatment and that recovered after that contraceptive treatment was restarted is reported.
Distinct CholinomiR Blood Cell Signature as a Potential Modulator of the Cholinergic System in Women with Fibromyalgia Syndrome
An FMS-specific CholinomiR signature in whole blood is identified, modulating immune-related gene expression, and is identified as a strong modulator of CNS and PNS immune processes.
Autonomic Nervous System Dysregulation and Osteoarthritis Pain: Mechanisms, Measurement, and Future Outlook
The autonomic nervous system appears to be dysregulated in OA progression, and further research on rebalancing autonomic function may lead to novel therapeutic strategies for treating OA pain.


Fibromyalgia: the nerve of that disease.
It is proposed that activity in vagal afferents, arising from the gastrointestinal tract, and sympathoadrenal function mediate a contribution of stress to FM and its strong association with irritable bowel syndrome.
Neurobiology of depression, fibromyalgia and neuropathic pain.
Recent data suggesting that the high rates of comorbidity observed between major depression, fibromyalgia and neuropathic pain likely result from the fact that these disorders share multiple biological and environmental underpinnings are synthesized.
Pathophysiology of fibromyalgia.
  • L. Bradley
  • Medicine
    The American journal of medicine
  • 2009
Fibromyalgia: A Stress Disorder?
The function of the stress response system is reviewed, placing special emphasis on the relationships between adverse life experiences, stress regulation and pain-processing mechanisms, and the evidence for a possible aetiopathogenetic role of stress in FM is summarized.
Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders
Various functions of the vagus nerve are discussed, which make it an attractive target in treating psychiatric and gastrointestinal disorders and preliminary evidence for gut bacteria to have beneficial effect on mood and anxiety, partly by affecting the activity of thevagus nerve.
Fibromyalgia: A Unifying Neuroendocrinologic Model for Understanding Its Pathophysiology
A neuroendocrinologic model of fibromyalgia is presented that accommodates both its known central and peripheral pain mechanisms as well as the myriad of hormonal, visceral, and psychological symptoms associated with that disorder.
Psychological impact of fibromyalgia: current perspectives
Psychological interventions may constitute a beneficial complement to pharmacological treatments in order to improve clinical symptoms and reduce the impact of FMS on health-related quality of life.
Dysfunctional Neurotransmitter Systems in Fibromyalgia, Their Role in Central Stress Circuitry and Pharmacological Actions on These Systems
The finding that not all fibromyalgia patients respond to the same medications, targeting dysfunctional transmitter systems, further supports the hypothesis that both transmitter and stress systems change in parallel, interact, and contribute to the phenotype of Fibromyalgia.
Cytokines and depression in cases with fibromyalgia.
IL-8 may play an important role in the occurrence of pain in FM, and was found to be related to pain intensity in patients with FM.
Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia
Fibromyalgia is proposed to be a sympathetically maintained neuropathic pain syndrome, and genomic data support this contention, and autonomic dysfunction may also explain other fibromyalgia features not related to pain.