The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats.

  title={The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats.},
  author={Shuichi Koda and Yukari Date and Noboru Murakami and Takuya Shimbara and Takeshi Hanada and Koji Toshinai and Akira Niijima and Mayumi Furuya and Norio Inomata and Kazuhiro Osuye and Masamitsu Nakazato},
  volume={146 5},
Peptide YY (PYY), an anorectic peptide, is secreted postprandially from the distal gastrointestinal tract. PYY(3-36), the major form of circulating PYY, binds to the hypothalamic neuropeptide Y Y2 receptor (Y2-R) with a high-affinity, reducing food intake in rodents and humans. Additional gastrointestinal hormones involved in feeding, including cholecystokinin, glucagon-like peptide 1, and ghrelin, transmit satiety or hunger signals to the brain via the vagal afferent nerve and/or the blood… CONTINUE READING
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