The role of the tumor suppressor p53 pathway in the cellular DNA damage response to zinc oxide nanoparticles.

@article{Ng2011TheRO,
  title={The role of the tumor suppressor p53 pathway in the cellular DNA damage response to zinc oxide nanoparticles.},
  author={Kee Woei Ng and Stella P K Khoo and Boon Chin Heng and Magdiel Inggrid Setyawati and Eng Chok Tan and Xin Zhao and Sijing Xiong and Wanru Fang and David Tai Leong and Joachim Say-Chye Loo},
  journal={Biomaterials},
  year={2011},
  volume={32 32},
  pages={
          8218-25
        }
}
In this paper, we explored how ZnO nanoparticles cross-interact with a critical tumor suppressive pathway centered around p53, which is one of the most important known tumor suppressors that protects cells from developing cancer phenotypes through its control over major pathways like apoptosis, senescence and cell cycle progression. We showed that the p53 pathway was activated in BJ cells (skin fibroblasts) upon ZnO nanoparticles treatment with a concomitant decrease in cell numbers. This… CONTINUE READING
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