The role of the thyrotropin-releasing hormone (TRH) neuron as a metabolic sensor.

  title={The role of the thyrotropin-releasing hormone (TRH) neuron as a metabolic sensor.},
  author={Anthony N. Hollenberg},
  journal={Thyroid : official journal of the American Thyroid Association},
  volume={18 2},
Thyroid hormone (TH) plays a critical role in mediating changes in development and metabolism in humans. Thus, circulating TH levels are regulated by a number of distinct mechanisms to allow them to remain at physiologic levels. The central regulation of the thyroid axis by thyrotropin-releasing hormone (TRH) neurons in the paraventricular nucleus of the hypothalamus (PVH) is absolutely required for normal function of the axis. Remarkably, the TRH neurons in the PVH are regulated by multiple… CONTINUE READING
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