The role of the testicular factor INSL3 in establishing the gonadal position.

@article{Adham2000TheRO,
  title={The role of the testicular factor INSL3 in establishing the gonadal position.},
  author={Ibrahim M. Adham and Judith M. A. Emmen and Wolfgang Engel},
  journal={Molecular and cellular endocrinology},
  year={2000},
  volume={160 1-2},
  pages={11-6}
}
INSL3, also designated Leydig insulin-like (Ley I-L) or relaxin-like factor (RLF), belongs to the insulin-like hormone superfamily. It is expressed in pre- and postnatal Leydig cells of the testis and in postnatal theca cells of the ovary. This sexual dimorphic pattern of INSL3 expression during development led us to suggest that the INSL3 factor could play an essential role in sexual differentiation, gonadal function and germ cell development. Key insights into the role of INSL3 came from… CONTINUE READING

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