The role of the hypothalamic-pituitary-adrenocortical system during inflammatory conditions.

@article{Schbitz1994TheRO,
  title={The role of the hypothalamic-pituitary-adrenocortical system during inflammatory conditions.},
  author={B Sch{\"o}bitz and Johannes M. H. M. Reul and Florian Holsboer},
  journal={Critical reviews in neurobiology},
  year={1994},
  volume={8 4},
  pages={263-91}
}
Infections and injury are often accompanied by the production of large quantities of proinflammatory mediators such as cytokines and eicosanoids. These substances have been shown to efficiently activate the hypothalamic-pituitary-adrenocortical (HPA) system. The glucocorticoid hormones secreted from the adrenal cortex seem to be crucial for survival because they have an inhibitory influence on inflammatory processes, which, if uncontrolled, may become toxic for the host. Furthermore, these… CONTINUE READING
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