The role of the superoxide and hydroxyl radicals in the degradation of DNA and deoxyribose induced by a copper-phenanthroline complex.

Abstract

DNA degradation by a copper(II)-phenanthroline complex was studied in the presence of NADH, 2-mercaptoethanol or a mixture of hypoxanthine and xanthine oxidase, which generates the superoxide radical, O2-. In all cases degradation was prevented by catalase but not by scavengers of the hydroxyl radical, OH. It remains possible, however, that OH was generated… (More)

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