The role of the striatal dopamine transporter in cognitive aging.

  title={The role of the striatal dopamine transporter in cognitive aging.},
  author={Nina Erixon-Lindroth and Lars Farde and Tarja-Brita Robins Wahlin and Judit Sovago and Christer Halldin and Lars B{\"a}ckman},
  journal={Psychiatry research},
  volume={138 1},
We examined the relationship of age-related losses of striatal dopamine transporter (DAT) density to age-related deficits in episodic memory and executive functioning in a group of subjects (n = 12) ranging from 34 to 81 years of age. The radioligand [(11)C]beta-CIT-FE was used to determine DAT binding in caudate and putamen. Results showed clear age-related losses of striatal DAT binding from early to late adulthood, and a marked deterioration in episodic memory (word and figure recall, face… CONTINUE READING
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