The role of the renin-angiotensin system in the pathophysiology of cardiac remodeling.

@article{Booz1996TheRO,
  title={The role of the renin-angiotensin system in the pathophysiology of cardiac remodeling.},
  author={George W Booz and Kenneth M. Baker},
  journal={Blood pressure. Supplement},
  year={1996},
  volume={2},
  pages={10-8}
}
Cardiac hypertrophy of diverse etiologies is associated with two remodeling events: an increase in cardiac muscle mass, and the abnormal accumulation of fibrillar collagen, which results in increased myocardial stiffness and eventual ventricular dysfunction. Clinical and animal studies have implicated angiotensin II (A II) as a growth promoter of both cardiac myocytes and fibroblasts during the cardiac remodeling that occurs with hypertension and myocardial infarction. The growth-promoting… CONTINUE READING