The role of the renin-angiotensin system in cisplatin nephrotoxicity.

@article{Deegan1995TheRO,
  title={The role of the renin-angiotensin system in cisplatin nephrotoxicity.},
  author={P M Deegan and Coleen Nolan and Michael P. Ryan and Mark A. Basinger and Mark M. Jones and Kenneth R. Hande},
  journal={Renal failure},
  year={1995},
  volume={17 6},
  pages={665-74}
}
The role of the renin-angiotensin system (RAS) in the pathogenesis of cisplatin nephrotoxicity was evaluated in an experimental rat model using a specific, nonpeptide angiotensin II(AII) receptor blocker, losartan. Rats were treated with a single dose of losartan (at 10 mg/kg and 30 mg/kg, i.p.) or saline, 2 h prior to cisplatin administration (5 mg/kg, i.p.). Renal function was assessed 3 and 7 days after cisplatin treatment. A second group of rats received losartan (10 mg/kg, i.p.) or saline… CONTINUE READING
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