The role of the regulatory subunit of fission yeast calcineurin for in vivo activity and its relevance to FK506 sensitivity.

@article{Sio2005TheRO,
  title={The role of the regulatory subunit of fission yeast calcineurin for in vivo activity and its relevance to FK506 sensitivity.},
  author={Susie Ong Sio and Takafumi Suehiro and Reiko Sugiura and Mai Takeuchi and Hideyuki Mukai and Takayoshi Kuno},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 13},
  pages={12231-8}
}
Calcineurin, a protein phosphatase required for Ca2+ signaling in many cell types, is a heterodimer composed of catalytic and regulatory subunits. The fission yeast genome encodes a single set of catalytic (Ppb1) and regulatory (Cnb1) subunits, providing an ideal model system to study the functions of these subunits in vivo. Here, we cloned the cnb1+ gene and showed that the cnb1 knock-out (Deltacnb1) exhibits identical phenotypes with Deltappb1 and that overexpression of Ppb1 failed to… CONTINUE READING

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