The role of the regulatory enzymes of catecholamine synthesis in Parkinson's disease.

@article{Goldstein1992TheRO,
  title={The role of the regulatory enzymes of catecholamine synthesis in Parkinson's disease.},
  author={Manfred Goldstein and Alon Lieberman},
  journal={Neurology},
  year={1992},
  volume={42 4 Suppl 4},
  pages={
          8-12; discussion 41-8
        }
}
The major neuropathology of Parkinson's disease (PD) is the degeneration of nigrostriatal dopamine (DA), resulting in a deficiency of DA, and of the enzyme tyrosine hydroxylase (TH), which catalyzes the synthesis of L-dopa. The symptomatic treatment of PD consists of replenishing DA by administering L-dopa, which is enzymatically converted to DA in the striatum. The increase of TH activity by modification of the enzyme leads to an increased synthesis of striatal L-dopa, and thereby replenishes… CONTINUE READING

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