The role of the proximal tubule in ochratoxin A nephrotoxicity in vivo: toxodynamic and toxokinetic aspects.

@article{Gekle1994TheRO,
  title={The role of the proximal tubule in ochratoxin A nephrotoxicity in vivo: toxodynamic and toxokinetic aspects.},
  author={Michael Gekle and Stefan Silbernagl},
  journal={Renal physiology and biochemistry},
  year={1994},
  volume={17 1},
  pages={40-9}
}
The proximal tubule of the kidney is regarded the main intrarenal target of the nephrotoxin Ochratoxin A (OTA). To gain further insight into the importance of the proximal tubule we investigated renal p-aminohippurate (PAH), inorganic phosphate (P), amino acid (AA) and OTA handling in male Wistar rats. The acute application of OTA (1.2 mg/kg) did not affect the renal handling of any of the substances investigated in contrast to the acute effect of OTA on 'postproximal' parts of the nephron… CONTINUE READING

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