The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations.


A widely dispersed network of hypothalamic GnRH neurons controls the reproductive axis in mammals. Genetic investigation of the human disease model of isolated GnRH deficiency has revealed several key genes crucial for GnRH neuronal ontogeny and GnRH secretion. Among these genes, prokineticin 2 (PROK2), and PROK2 receptor (PROKR2) have recently emerged as… (More)
DOI: 10.1210/er.2010-0007


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